Fine feathers : some aspects of the art of costume : inaugural lecture delivered at Rhodes University

Inaugural lecture delivered at Rhodes UniversityRhodes University Libraries (Digitisation

The Dual Enrollment Challenges of First-Generation Appalachian College Students: A Holistic Single-Case Study

The purpose of this holistic single-case study was to describe the dual enrollment experiences of first-generation Appalachian college students in Southwest Virginia. The theory guiding this study was Tinto’s theory of college student retention as it related to first-generation Appalachian college students who have taken dual enrollment courses. To further understand the challenges faced by these students the following research question was posed: What are student, teacher, and administrator descriptions of the challenges faced by first-generation college students taking dual enrollment courses in Southwest Virginia? Subquestions served to investigate the role of dual enrollment courses on the college involvement, college retention, and degree completion of first-generation Appalachian college students. The participants for this study included 11 individuals who were first-generation Appalachian college students who graduated from high school and were enrolled in dual enrollment courses in high school; dual enrollment instructors; school guidance counselors or principals; and dual enrollment program administrators. Data were collected via individual interviews, online focus group interviews, and reflective journals. Data were analyzed by transcribing interviews, identifying and grouping themes, and constructing a narrative that can provide information on the experiences of first-generation college students taking dual enrollment courses in the Appalachian region. Findings indicated parents may not have had the knowledge to support their children who were taking dual enrollment courses academically; however, they were able to significantly support them emotionally and financially throughout the process. This study also found dual enrollment courses are a generally positive experience for first-generation students in the Appalachian region and the support of their parents played a key role in this positive experience

Device to measure axial displacement in a borehole

A device to measure minute displacement in rocks, including anchor deployment means, anchor registration means, and frame release means. Further including anchor units comprising a fixed anchor point, a reversible anchor actuator and a deployable anchor face capable of being deployed with a force of up to 2000 lbs

Exploring the Spectral Space of Low Redshift QSOs

The Karhunen-Loeve (KL) transform can compactly represent the information contained in large, complex datasets, cleanly eliminating noise from the data and identifying elements of the dataset with extreme or inconsistent characteristics. We develop techniques to apply the KL transform to the 4000-5700A region of 9,800 QSO spectra with z < 0.619 from the SDSS archive. Up to 200 eigenspectra are needed to fully reconstruct the spectra in this sample to the limit of their signal/noise. We propose a simple formula for selecting the optimum number of eigenspectra to use to reconstruct any given spectrum, based on the signal/noise of the spectrum, but validated by formal cross-validation tests. We show that such reconstructions can boost the effective signal/noise of the observations by a factor of 6 as well as fill in gaps in the data. The improved signal/noise of the resulting set will allow for better measurement and analysis of these spectra. The distribution of the QSO spectra within the eigenspace identifies regions of enhanced density of interesting subclasses, such as Narrow Line Seyfert 1s (NLS1s). The weightings, as well as the inability of the eigenspectra to fit some of the objects, also identifies "outliers," which may be objects that are not valid members of the sample or objects with rare or unique properties. We identify 48 spectra from the sample that show no broad emission lines, 21 objects with unusual [O III] emission line properties, and 9 objects with peculiar H-beta emission line profiles. We also use this technique to identify a binary supermassive black hole candidate. We provide the eigenspectra and the reconstructed spectra of the QSO sample.Comment: 34 pages, 14 figures, revised version resubmitted to the Astronomical Journa

Neonatal Pain-Related Stress Predicts Cortical Thickness at Age 7 Years in Children Born Very Preterm

Background Altered brain development is evident in children born very preterm (24–32 weeks gestational age), including reduction in gray and white matter volumes, and thinner cortex, from infancy to adolescence compared to term-born peers. However, many questions remain regarding the etiology. Infants born very preterm are exposed to repeated procedural pain-related stress during a period of very rapid brain development. In this vulnerable population, we have previously found that neonatal pain-related stress is associated with atypical brain development from birth to term-equivalent age. Our present aim was to evaluate whether neonatal pain-related stress (adjusted for clinical confounders of prematurity) is associated with altered cortical thickness in very preterm children at school age. Methods 42 right-handed children born very preterm (24–32 weeks gestational age) followed longitudinally from birth underwent 3-D T1 MRI neuroimaging at mean age 7.9 yrs. Children with severe brain injury and major motor/sensory/cognitive impairment were excluded. Regional cortical thickness was calculated using custom developed software utilizing FreeSurfer segmentation data. The association between neonatal pain-related stress (defined as the number of skin-breaking procedures) accounting for clinical confounders (gestational age, illness severity, infection, mechanical ventilation, surgeries, and morphine exposure), was examined in relation to cortical thickness using constrained principal component analysis followed by generalized linear modeling. Results After correcting for multiple comparisons and adjusting for neonatal clinical factors, greater neonatal pain-related stress was associated with significantly thinner cortex in 21/66 cerebral regions (p-values ranged from 0.00001 to 0.014), predominately in the frontal and parietal lobes. Conclusions In very preterm children without major sensory, motor or cognitive impairments, neonatal pain-related stress appears to be associated with thinner cortex in multiple regions at school age, independent of other neonatal risk factors

Life on Jackson Creek, Smith County, Texas: Archeological Investigations of a 14th Century Caddo Domicile at the Leaning Rock Site (41SM325)

The 14th century Caddo Leaning Rock site was initially discovered in the Fall of 2004. It was located during reconnaissance to search out a location for the survey portion of the Texas Archeologica! Society\u27s Academy IO I held in Tyler in February 2005. This was not a formal survey with transect lines. nor one using regularly spaced shovel tests. but was rather more of a windshield \u27 type survey, consisting of driving across pasture lands looking at gopher mounds and checking fore, evidence of archeological deposits on likely looking landforms. !n this area. landform and soil type seem to be the major determining factors in locating Caddo sites. The sandy soils in the scattered gopher mounds appeared almost white. especially in droughty conditions that prevailed at the time. causing an area with darker mounds of soil to catch my attention. Pocket gophers (G. breviceps) can play havoc with buried archeological deposits but can also be useful in bringing buried soils along with archeological materials to the surface from their underground tunnel system. While this dark area could have been the result of past historic land clearing and burning activities. a closer inspection revealed burned bone. mussel she!L and Caddo sherds mixed in the dark brown soils in the scattered gopher mounds. The next step was to record the site with the State of Texas, obtaining the trinomial 41SM325. It is common practice to also gin: sites informal names and after recording several hundred sites, selecting a name becomes a challenge. One large sandstone slab, pan of the R-horizon that is exposed around the margins of Leaning Rock. was unearthed during prior landclearing activities and pushed up against a lonely pine tree on the northern margins of the site: consequently the nom de plume Leaning Rock

Human Oncoprotein 5MP Suppresses General and Repeat-Associated Non-AUG Translation via eIF3 by a Common Mechanism

eIF5-mimic protein (5MP) is a translational regulatory protein that binds the small ribosomal subunit and modulates its activity. 5MP is proposed to reprogram non-AUG translation rates for oncogenes in cancer, but its role in controlling non-AUG initiated synthesis of deleterious repeat-peptide products, such as FMRpolyG observed in fragile-X-associated tremor ataxia syndrome (FXTAS), is unknown. Here, we show that 5MP can suppress both general and repeat-associated non-AUG (RAN) translation by a common mechanism in a manner dependent on its interaction with eIF3. Essentially, 5MP displaces eIF5 through the eIF3c subunit within the preinitiation complex (PIC), thereby increasing the accuracy of initiation. In Drosophila, 5MP/Kra represses neuronal toxicity and enhances the lifespan in an FXTAS disease model. These results implicate 5MP in protecting cells from unwanted byproducts of non-AUG translation in neurodegeneration

A View of Tropical Cyclones from Above: The Tropical Cyclone Intensity Experiment

Tropical cyclone (TC) outflow and its relationship to TC intensity change and structure were investigated in the Office of Naval Research Tropical Cyclone Intensity (TCI) field program during 2015 using dropsondes deployed from the innovative new High-Definition Sounding System (HDSS) and remotely sensed observations from the Hurricane Imaging Radiometer (HIRAD), both on board the NASA WB-57 that flew in the lower stratosphere. Three noteworthy hurricanes were intensively observed with unprecedented horizontal resolution: Joaquin in the Atlantic and Marty and Patricia in the eastern North Pacific. Nearly 800 dropsondes were deployed from the WB-57 flight level of ∼60,000 ft (∼18 km), recording atmospheric conditions from the lower stratosphere to the surface, while HIRAD measured the surface winds in a 50-km-wide swath with a horizontal resolution of 2 km. Dropsonde transects with 4–10-km spacing through the inner cores of Hurricanes Patricia, Joaquin, and Marty depict the large horizontal and vertical gradients in winds and thermodynamic properties. An innovative technique utilizing GPS positions of the HDSS reveals the vortex tilt in detail not possible before. In four TCI flights over Joaquin, systematic measurements of a major hurricane’s outflow layer were made at high spatial resolution for the first time. Dropsondes deployed at 4-km intervals as the WB-57 flew over the center of Hurricane Patricia reveal in unprecedented detail the inner-core structure and upper-tropospheric outflow associated with this historic hurricane. Analyses and numerical modeling studies are in progress to understand and predict the complex factors that influenced Joaquin’s and Patricia’s unusual intensity changes

Assessing Tourism Development from Sen’s Capability Approach

The purpose of this study is to assess tourism development in the context of Sen’s capability approach. The study developed a model to investigate the relationship between tourism development and human development while focusing on two countries, Nicaragua and Costa Rica. The study applied a cointegration technique based on the Granger representation theorem. Overall, tourism development and human development reveals a tenuous relationship in both cases, reflecting some threshold effect. The importance of tourism growth is merited in the distribution of its benefits and the extent that tourism receipts are allocated to support human development (public health, education, safety, etc.). Rising incomes will not necessarily translate into human development performance, thereby rendering support to Sen’s contention that well-being should not be measured by its instrumental antecedents (such as income) alone. Private incomes through tourism expansion seem to matter most at lower levels of human development

Correlations between Diffusion Tensor Imaging (DTI) and Magnetic Resonance Spectroscopy (1H MRS) in schizophrenic patients and normal controls

<p>Abstract</p> <p>Background</p> <p>Evidence suggests that white matter integrity may play an underlying pathophysiological role in schizophrenia. N-acetylaspartate (NAA), as measured by Magnetic Resonance Spectroscopy (MRS), is a neuronal marker and is decreased in white matter lesions and regions of axonal loss. It has also been found to be reduced in the prefrontal and temporal regions in patients with schizophrenia. Diffusion Tensor Imaging (DTI) allows one to measure the orientations of axonal tracts as well as the coherence of axonal bundles. DTI is thus sensitive to demyelination and other structural abnormalities. DTI has also shown abnormalities in these regions.</p> <p>Methods</p> <p>MRS and DTI were obtained on 42 healthy subjects and 40 subjects with schizophrenia. The data was analyzed using regions of interests in the Dorso-Lateral Prefrontal white matter, Medial Temporal white matter and Occipital white matter using both imaging modalities.</p> <p>Results</p> <p>NAA was significantly reduced in the patient population in the Medial Temporal regions. DTI anisotropy indices were also reduced in the same Medial Temporal regions. NAA and DTI-anisotropy indices were also correlated in the left medial temporal region.</p> <p>Conclusion</p> <p>Our results implicate defects in the medial temporal white matter in patients with schizophrenia. Moreover, MRS and DTI are complementary modalities for the study of white matter disruptions in patients with schizophrenia.</p